Protective effects of resveratrol on permethrin-induced fetotoxicity in rats

Synthetic pyrethroid insecticides have been widely used for years to prevent harmful effects of insects and control disease vectors. In this study, the resveratrol against potential toxicity permethrin, an effective derivative, on fetus were investigated. Accordingly, Wistar female rats divided into four groups as Control, Sham, Permethrin, Permethrin + Resveratrol. Lung, liver, kidney small intestine developing fetuses evaluated histopathologically. Also, Bone Morphogenetic Protein-4 (BMP-4) in bone tissue development Fibroblast Growth Factor-1 (FGF-1) expressions lung examined immunohistochemically. All structures Control Sham normal. caused epithelial damage, regression bronchial primitive alveolar lung; congestion, edema sinusoidal dilatation around central vein liver; tubular degeneration, glomeruli tubule formation kidney; degeneration irregularity villus structure intestine. Immunohistochemical results indicated that permethrin administration decreased BMP-4 levels FGF-1 lung. Resveratrol application was found greatly alleviate histopathological immunohistopathological variability all tissues. Oral consumption by pregnant growth retardation damage many different tissues offspring. Intake during pregnancy showed protective fetotoxicity permethrin.